A collaborative discussion with Dr. Perry Cabot of Colorado State University, Aaron Derwingson of The Nature Conservancy’s Colorado River Program, and Paul Bruchez, Farmer and Member of the Colorado Water Conservation Board discuss their large-scale depletion accounting pilot project. We discuss the role of Open ET satellite imaging to determine actual evaporative losses from crops as well as on-going on-farm mitigation and operational studies to promote farm health in the face of water shortage and drought.